GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7095944 | 1 | rs7095944 | chr10:126302936 | METTL10 | chr10:126447406-126480439:- | -0.36 | -4.48 | 2.08E-5 | Asthma |
| THYM | cis | rs2243480 | 1 | rs709607 | chr7:65449541 | CCT6P1 | chr7:65216092-65228661:+ | -0.65 | -5.31 | 7.32E-7 | Diabetic kidney disease |
| THYM | cis | rs12780845 | 1 | rs7096692 | chr10:17180828 | CUBN | chr10:16865966-17171816:- | 0.32 | 4.99 | 2.69E-6 | Homocysteine levels |
| THYM | cis | rs4409766 | 1 | rs7098825 | chr10:104628234 | SFXN2 | chr10:104474298-104498946:+ | -0.55 | -4.43 | 2.49E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| THYM | cis | rs12780845 | 1 | rs7100163 | chr10:17181177 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.72 | 8.1E-6 | Homocysteine levels |
| THYM | cis | rs2028299 | 1 | rs7111 | chr15:90373873 | AP3S2 | chr15:90373832-90456222:- | -0.42 | -4.83 | 5.23E-6 | Type 2 diabetes |
| THYM | cis | rs4237643 | 1 | rs7115737 | chr11:43681249 | HSD17B12 | chr11:43702143-43878160:+ | -0.59 | -5.94 | 4.7E-8 | Forced vital capacity |
| THYM | cis | rs7849270 | 1 | rs713219 | chr9:131900920 | CRAT | chr9:131857075-131873070:- | 0.42 | 4.98 | 2.82E-6 | Blood metabolite ratios |
| THYM | cis | rs71327718 | 1 | rs71327718 | chr3:125592857 | LOC100125556 | chr3:125635444-125648865:+ | 0.67 | 4.26 | 4.8E-5 | Metabolite levels (HVA/5-HIAA ratio) |
| THYM | cis | rs911119 | 1 | rs71334202 | chr20:23618652 | CST9 | chr20:23583049-23586610:- | -0.47 | -4.35 | 3.48E-5 | Chronic kidney disease |
| THYM | cis | rs4663866 | 1 | rs71426508 | chr2:239137767 | LOC151174 | chr2:239133754-239140318:- | 1.02 | 4.78 | 6.5E-6 | Irritable bowel syndrome |
| THYM | cis | rs4663866 | 1 | rs71426509 | chr2:239175334 | LOC151174 | chr2:239133754-239140318:- | 0.93 | 4.57 | 1.47E-5 | Irritable bowel syndrome |
| THYM | cis | rs4663866 | 1 | rs71426510 | chr2:239178909 | LOC151174 | chr2:239133754-239140318:- | 0.93 | 4.57 | 1.47E-5 | Irritable bowel syndrome |
| THYM | cis | rs2143950 | 1 | rs7144423 | chr14:35572547 | KIAA0391 | chr14:35591776-35786673:+ | 0.37 | 4.81 | 5.59E-6 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs7144423 | chr14:35572547 | PPP2R3C | chr14:35554679-35591679:- | 0.28 | 5.24 | 9.78E-7 | Atopic dermatitis |